CD8-PC7, SFCI21Thy2D3, 100 Tests, CE

Product No:737661

The CD8 antigen is a disulfide-linked dimer, which exists either as a CD8α homodimer or as a CD8α/β heterodimer. CD8α is required for surface expression of CD8β. The molecular weight of each monomer of α or β is approximately 32-34 kDa. CD8 binds to a non-polymorphic domain (α3 domain) of MHC Class I molecules. CD8 is expressed on a subset of human peripheral blood T lymphocytes. A subset of NK cells possess the CD8 antigen but show low to medium density of expression. CD8α homodimer is expressed by NK cells and γ/δ+ T cells. CD8 is also present on most thymocytes where it is frequently co-expressed with CD4, and on a subpopulation of bone marrow cells. The CD8 molecule acts with the T Cell Receptor (TCR) as a coreceptor for MHC class I restricted antigen recognition. CD8 is widely used as a marker of cytotoxic T lymphocytes.

$1,037.00 List Price - $1,037.00


Product Specifications

Target Species Human
Specificity CD8
Other Names CD8, T8 antigen
Fluorochrome PC7
Regulatory Status CE
Size 100 Tests
Format Liquid
Flow Product Line IOTest
Clone SFCI21Thy2D3
Isotype IgG1 Mouse
Clone Description SFCI21Thy2D3 monoclonal antibody recognizes the α chain of the CD8 molecule.
Cross Reactivity Common Marmoset

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