CD64-APC-A750 Conjugated Antibody

B96769

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CD64 is an integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is also known as Fc-gamma receptor 1 (FcγRI) or FCRI. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain, triggering cellular activation. Structurally, CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on macrophages and monocytes. CD64 is expressed on early myeloid cells and in IFNγ and G-CSF activated polymorphonuclear neutrophils (PMNs).

Specifications

Target Species Human
Specificity CD64
Other Names FcRI, FcgRI
Fluorochrome APC-Alexa Fluor* 750
Regulatory Status CE
Size 50 Tests
Format Liquid
Flow Product Line IOTest
Clone 22
Isotype IgG1 Mouse
Clone Description The 22 antibody shows especially high affinity binding to human mononuclear phagocytes. The epitope recognized by this antibody is disctinct from the IgG binding site.
Cross Reactivity Indian Rhesus
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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.