HIV Advanced Disease Management Solutions

Monitoring CD4 lymphocyte counts is essential in providing critical information that impacts patient care. CD4 monitoring allows caregivers to know when the disease transforms and stage its progression so they can implement the most appropriate intervention. Beckman Coulter has been providing cost effective solutions to monitor CD4 status in resource limited countries for several decades. The mounting HIV problem in these regions of the world has led to innovative solutions with a mission to deliver patient care.

Aquios CL_Accessories_Tubes_White_MedRes - Section 9

AQUIOS CL Flow Cytometry System: The first true Load & Go flow cytometer

Sample preparation and data management usually are the major bottlenecks in routine flow cytometry. Even with a semi-automated process, you and your team may spend hundreds of hours per year for tasks that don't add to your laboratory's productivity.

Work with a system that combines sample preparation, reagent management, barcode scanning and analysis in one compact platform.

  • Provide a 24/7 flow cytometry service as the AQUIOS CL can be run by less experienced operators.
  • Increase productivity with high-throughput performance that eliminates many of the least efficient features of existing systems.
  • Minimize the potential for user error inherent in existing systems that require numerous manual steps to set up and run.
  • Discover the AQUIOS Tetra System for Lymphocyte Subset Analysis, AQUIOS PLG or CD4 testing or automate your own user-defined assay with AQUIOS Designer Software.
  • Train in as little as one day for skilled flow cytometrists with computer based training videos.
  • AQUIOS CL with Tetra-1 has been accepted for the World Health Organization list of prequalified in vitro diagnostic products.

“Since it is so simple and intuitive, training my techs was a breeze. You could train them in less than an hour. So we were able to cross-train most of the techs in the area in very short time. That makes everything efficient in the laboratory.”

Alexandra Amador, MT (ASCP), CHT (ABHI), Manager Histocompatibility Lab, University of Miami.

AQUIOS CL Workflow: Eliminate Steps With Every Sample

Modular flow cytometry systems might be effective for higher complexity applications, but aren‘t the best option for efficiently managing a high volume of routine applications. With AQUIOS CL, you can automate your most routine, repetitive tasks.

 

 

Total elapsed time from instrument startup to shutdown was analyzed for 10, 25, and 50 lymphocyte subset samples on AQUIOS CL vs. the alternative method (FC500 with TQ-Prep). AQUIOS CL reduced actual hands-on time by up to 92%.

Reagents and sample material used: AQUIOS Tetra-1 with AQUIOS IMMUNO-TROL and AQUIOS IMMUNO-TROL Low cells (AQUIOS CL); CYTO-STAT tetraCHROME CD45/CD4/CD8/CD3 with IMMUNO-TROL and IMMUNO-TROL Low cells (FC500 with TQ-Prep).

Data: The London Health Sciences Centre (Ontario, Canada).

FLOWC-HIV-aquios-reduces-hands-on-time - Section 9


Time to first result (sum of cytometer startup & cleaning, quality control, and sample preparation time including time for analysis of the first sample) was analyzed for 10, 25, and 50 lymphocyte subset samples on AQUIOS CL vs. the alternative method (BD FACSCalibur plus SPA II system).

Reagents and sample material used: BD MultiTest CD3/CD8/CD45/CD4 with BD Multi-Check and BD Multi-Check Low Control cells (FACSCalibur plus SPA II); AQUIOS Tetra-1 with AQUIOS IMMUNO-TROL and AQUIOS IMMUNO-TROL Low cells (AQUIOS CL). 

Data: University of Texas Medical Branch (UTMB), Galveston, Texas.

FLOWC-HIV-aquios-time-to-first-result - Section 9

AQUIOS CL Workflow: Eliminate Steps With Every Sample

Modular flow cytometry systems might be effective for higher complexity applications, but aren‘t the best option for efficiently managing a high volume of routine applications. With AQUIOS CL, you can automate your most routine, repetitive tasks.

 

 

Total elapsed time from instrument startup to shutdown was analyzed for 10, 25, and 50 lymphocyte subset samples on AQUIOS CL vs. the alternative method (FC500 with TQ-Prep). AQUIOS CL reduced actual hands-on time by up to 92%.

Reagents and sample material used: AQUIOS Tetra-1 with AQUIOS IMMUNO-TROL and AQUIOS IMMUNO-TROL Low cells (AQUIOS CL); CYTO-STAT tetraCHROME CD45/CD4/CD8/CD3 with IMMUNO-TROL and IMMUNO-TROL Low cells (FC500 with TQ-Prep).

Data: The London Health Sciences Centre (Ontario, Canada).

FLOWC-HIV-aquios-reduces-hands-on-time - Section 9


Time to first result (sum of cytometer startup & cleaning, quality control, and sample preparation time including time for analysis of the first sample) was analyzed for 10, 25, and 50 lymphocyte subset samples on AQUIOS CL vs. the alternative method (BD FACSCalibur plus SPA II system).

Reagents and sample material used: BD MultiTest CD3/CD8/CD45/CD4 with BD Multi-Check and BD Multi-Check Low Control cells (FACSCalibur plus SPA II); AQUIOS Tetra-1 with AQUIOS IMMUNO-TROL and AQUIOS IMMUNO-TROL Low cells (AQUIOS CL). 

Data: University of Texas Medical Branch (UTMB), Galveston, Texas.

FLOWC-HIV-aquios-time-to-first-result - Section 9

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Advanced Disease Management

FLOWC-HIV-PLG gating strategy - Section 9

PLG

By focusing on the most essential parameters for monitoring HIV therapies (CD45 vs CD4), AQUIOS PLG addresses cost, complexity, and the time previously required by labor-intensive processes to provide busy laboratories with an affordable, high-performance monitoring solution.
Flow cytometry_B23533_AQUIOS Tetra-1 - Section 9

Tetra

In the clinical management of immune deficiency diseases, accurately counting the absolute cell numbers of leukocyte subsets and measuring the percentage of individual subtypes in blood is critical. 

Aquios CL_Accessories_Tubes_White_MedRes - Section 9

Error Prevention During Quality Control on the AQUIOS CL System

The AQUIOS CL system employs several features that work to prevent errors during startup, cleaning, and worklist generation. These prevention methods can be broken down into the following

Aquios CL_Accessories_Tubes_White_MedRes - Section 9

Error Prevention Features of the AQUIOS CL Overview

Laboratory standards and regulations set forth by governmental bodies such as the Centers for Disease Control (CDC) help to define the procedures that laboratories follow.