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The CD71 antigen is known as the transferrin receptor. It mediates cellular iron uptake via internalization and recycling. It is a type II membrane glycoprotein, characterized as a disulfide-bound dimer of two identical subunits of 95 kDa each. CD71 is expressed on activated T and B lymphocytes, macrophages and erythroblasts. The N-Terminal, intracytoplasmic domain of CD71 mediates rapid endocytosis and self recycling. CD71 is absent from resting blood leucocytes. Its expression is upregulated on proliferating cells. CD71 is present on reticulocytes and erythroid progenitors in fetal liver, cord blood, and peripheral blood, yet it is lost as these differentiate to mature erythrocytes. CD71 is expressed on marrow stromal cells (MSCs) from bone marrow.
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