CD44 Antigen

The CD44 is a transmembrane glycoprotein of 85-200 KDa. Multiple CD44 isoforms have been described. CD44 is present on most cells or tissues, but not on platelets, hepatocytes, cardiac muscle, kidney tubular epithelium, testis and skin portions. CD44 is a signaling platform that integrates cellular microenvironmental cues with growth factor and cytokine signals. It transduces signals to membrane-associated cytoskeletal proteins or to the nucleus to regulate a variety of gene expression levels related to cell-matrix adhesion, cell migration, proliferation, differentiation, and survival. This cell adhesion molecule plays an important role in tumor progression and metastasis. Its role in tumorigenesis is due to its binding to extracellular matrix components, including hyaluronan (HA) and osteopontin (OPN), and to messenger molecules, such as growth factors present in the tumor microenvironment. The human Indian (In) blood group antigens a/b reside on CD44.


 Clone: J.173  Isotype: IgG1 Mouse

J.173 antibody does not inhibit the binding of hyaluronate to its receptor. It can trigger IL-2-dependent proliferation and cytotoxicity of human T cell clones in vitro.
 

 

Explore Beckman Coulter CD44 Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
ASR
J.173
0.5 mL
Buy
ASR
J.173
2 mL
Buy
ASR
J.173
2 mL
Buy
ASR
J.173
0.5 mL
Buy

Product Line Specifications

Format Liquid
Specificity CD44
Form Pacific Blue*
Clone J.173
Isotype IgG1 Mouse
Cross Reactivity Cynomolgus Monkey, Indian Rhesus, Olive Baboon
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B37789

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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