CD42b Antigen

The CD42b antigen (GPIbα) is a membrane glycoprotein of 135 kDa, that forms a disulfide linked 160 kDa membrane protein with the CD42c (GP1bβ) known as GP1b. GP1b forms a noncovalent complex with GPIX (CD42a) and GPV (CD42d). This antigen is found on platelets and megakaryocytes. It has also been reported on vascular and tonsillar endothelial cells. The CD42 complex serves as the von Willebrand Factor(vWF) surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls.


 Clone: SZ2  Isotype: IgG1 Mouse

The SZ2 monoclonal antibody prevents the ristocetin-dependent binding of von Willebrand's factor to platelets and inhibits ristocetin-induced platelet agglutination. Platelet aggregation induced by type I collagen and Platelet Activating Factor (PAF) is also inhibited. The SZ2 antibody immunoprecipitates the components of the GPIb complex. It may also be used in Western blot.
 

 

Explore Beckman Coulter CD42b Conjugated Antibodies

Part Number Product Name Status Clone Size List Price Buy
RUO
SZ2
0.2 mg / 0.2 mg
Buy
ASR
SZ2
0.5 mL
Buy
ASR
SZ2
2 mL
Buy
ASR
SZ2
2 mL
Buy

Product Line Specifications

Format Liquid
Specificity CD42b
Form APC
Clone SZ2
Isotype IgG1 Mouse
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B13980

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


Technical Documents