CD2 Antigen

The CD2 antigen (also called LFA-2 or T11 antigen) is a 50 kDa single chain type I transmembrane glycoprotein that comprises two external domains belonging to the immunoglobulin superfamily (IgSF). It was formerly described as the sheep red blood cell receptor, causing T-cell rosetting. Signaling molecules, such as Fyn, Lck and the PI3-kinase, have been reported to associate with the intracellular domain of CD2. CD2 has been identified as the ligand for CD58 (LFA-3). It is also a receptor for CD48, CD59 and CD15. The CD58-CD2 interaction is a component of intercellular adhesion and costimulatory signaling in T cells. CD2 is involved in the regulation of human T-cell cytokine production, and in a Fas-independent induced apoptosis of activated human peripheral T cells. CD2 is present on all human non-B peripheral lymphocytes, on the majority of thymic T cells, and on a subset of thymic B cells.


Clone: SFCI3Pt2H9 (T11)  Isotype: IgG1 Mouse

SFCI3Pt2H9 inhibits sheep erythrocyte rosette formation. It has been used as a CD2 reference monoclonal antibody during HLDA 6 (ref.6T-CD2.6).

Clone: 39C1.5 Isotype: IgG2a Rat

39C1.5 inhibits sheep erythrocyte rosette formation. It has been used as a CD2 reference monoclonal antibody during HLDA 6 (ref 6T-CD2.7).

 

Explore Beckman Coulter CD2 Conjugated Antibodies

Product Line Specifications

Format Liquid
Specificity CD2
Form APC-Alexa Fluor* 700
Clone 39C1.5
Isotype IgG2a, Rat
Cross Reactivity Cynomolgus Monkey, Hamadyras Baboon, Indian Rhesus, Capuchin Monkey, Common Marmoset, Equine, Olive Baboon, Squirrel Monkey
Target Species Human
Flow Product Line IOTest
Item Specifications Referenced B12111

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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