The Use of the Analytical Ultracentrifuge to Characterize Very Large Complex Biopharmaceuticals

Analytical Methods to Measure Empty and Full AAV Particles

Review around biophysical characterizing techniques and a focus on the use of analytical ultracentrifugation (AUC) for measuring empty and full AAV particles

Analytical Ultracentrifugation in the Biopharmaceutical Industry

Dr. Alexander Bepperling focuses on the data analysis tools to achieve high precision when analyzing biopharmaceutical products due to an interest in minor species of about 1-2% usually comprising of the total protein content. He focuses on the data analysis done in SEDFIT. Learn how to set up continuous c(S) distribution analysis as implemented with SEDFIT software for enhanced reproducibility during a study of many batches of one protein. Also covers applications of sedimentation equilibrium (SE) for screening weak interactions and determining detergent binding to proteins.

Development and Production of Viral Vectors: Advances in Processes and Translation for Human Gene Therapy

Understand the role viral vectors play in modern gene research and how ultracentrifugation is used to produce these key delivery systems