TCR Vβ11-PE

IM2290


Flow Reagents Icon Antibodies and Kits
Also called TCRBV11S1 Vβ11 is the human variable β11 chain of the T cell receptor. Two Vβ11 sequences are described, PL3.12 and PH15. These sequences differ only in their leader sequence and therefore lead to the same mature protein. An invariant Vα24/Vβ11 T cell receptor is expressed in all individuals by clonal expanded CD4– CD8– T cells, reactive to bacterial antigens. This unique lymphocyte population restricted by the CD1d molecule recognition has been identified as the natural killer T (NKT) cells. Vβ11 is expressed by 0.4% to 0.9% of peripheral CD3+ cells in normal blood. This sequence is also referred to as TRBV25-1 (based on the IMGT gene nomenclature).

Specifications

Target Species Human
Specificity TCR Vβ11
Other Names TCR VBeta 11, TCRBV11S1
Fluorochrome PE
Regulatory Status ASR
Size 1 mL
Format Liquid
Flow Product Line IOTest
Clone C21
Isotype IgG2a Mouse
Clone Description The C21 recognizes the gene product of  PL3.12 and PH15 sequences. The specificity of this antibody has been confirmed at the First Human TcR Monoclonal Antibody Workshop in San Francisco in 1995.

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The listed regulatory status for products correspond to one of the below:
IVD: In Vitro Diagnostic Products. These products are labeled "For In Vitro Diagnostic Use."
ASR: Analyte Specific Reagents. These reagents are labeled "Analyte Specific Reagents. Analytical and performance characteristics are not established."
CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (Note: Devices may be CE marked to other directives than (98/79/EC)
RUO: Research Use Only. These products are labeled "For Research Use Only. Not for use in diagnostic procedures."
LUO: Laboratory Use Only. These products are labeled "For Laboratory Use Only."
No Regulatory Status: Non-Medical Device or non-regulated articles. Not for use in diagnostic or therapeutic procedures.